In Anaconda 5: Bloodline, a biotech corporation revives the original giant anaconda’s DNA, creating a genetically-enhanced hybrid with heightened intelligence and regenerative abilities. Set deep in the Congo Basin, a team of scientists led by Dr. Lena Cruz uncovers an ancient temple linked to a cult that once worshipped giant serpents. As the hybrid snake escapes containment, it begins hunting anyone near the sacred grounds, seemingly drawn by something older and darker than science can explain.

Tensions rise as the team realizes one of them is secretly working with the corporation to secure live DNA. In the explosive climax, Lena uses ancient venom-laced relics to weaken the beast. The film ends with a twist: a hidden nest with multiple eggs begins to hatch—setting the stage for another sequel. Anaconda 5 blends science fiction and jungle horror in the franchise’s most supernatural entry yet.